Cell Surface N-Glycans Influence Electrophysiological Properties and Fate Potential of Neural Stem Cells
نویسندگان
چکیده
منابع مشابه
Hydrogel/electrospun fiber composites influence neural stem/progenitor cell fate
Cell replacement therapy with multi-potent neural stem/progenitor cells (NSPCs) into the injured spinal cord is limited by poor survival and host tissue integration. An injectable and biocompatible polymeric cell delivery system serves as a promising strategy to facilitate cell delivery, promote cell survival and direct cell behaviour. We developed and characterized the use of a physical hydrog...
متن کاملImmunohistological and electrophysiological characterization of Globose basal stem cells
Objective(s): In the past few decades, variety of foetal, embryonic and adult stem and progenitor cells have been tried with conflicting outcome for cell therapy of central nervous system injury and diseases. Cellular characteristics and functional plasticity of Globose basal stem cells (GBCs) residing in the olfactory epithelium of rat olfactory mucosa have not been studied in the past by the ...
متن کاملCell surface N-glycans influence the level of functional E-cadherin at the cell–cell border
E-cadherin is crucial for adhesion of cells to each other and thereby development and maintenance of tissue. While it is has been established that N-glycans inside the cell impact the level of E-cadherin at the cell surface of epithelial-derived cells, it is unclear whether N-glycans outside the cell control the clustering of E-cadherin at the cell-cell border. Here, we demonstrate reduction of...
متن کاملEpigenetic control of neural stem cell fate.
Unraveling the mechanisms by which neural stem cells generate distinct cell types remains a central challenge in central nervous system (CNS) biology. Recent studies have shown that epigenetic gene regulation plays an important role in the control of cell growth and differentiation. These epigenetic controls cover a wide spectrum, including the interaction of chromatin remodeling enzymes with n...
متن کاملNeural Fate of Mesenchymal Stem Cells and Neural Crest Stem Cells: Which Ways to Get Neurons for Cell Therapy Purpose?
The treatment of neurological disorders represents a critical issue in clinical research, since no complete recovery of patients can be achieved with actual therapeutic means, despite symptomatic improvements. Indeed, whereas restricted brain areas still house cells compe‐ tent to generate newborn neurons in adulthood, those neural stem cells are present in re‐ stricted amounts. Moreover, this ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Stem Cell Reports
سال: 2018
ISSN: 2213-6711
DOI: 10.1016/j.stemcr.2018.08.011